For normal scans I use 300 dpi, but for scans of my coins I use 1200 dpi. It takes longer and the files are much larger then, but you can see every detail of the coins this way.
Or you can choose for the happy medium and choose for 600 dpi.
No special settings, really. You do have to make sure the coin is flat on the glass, though. Anything like a plastic capsule or curved staples in a 2x2 holder that increases the distance or causes reflection/puts it out of focus and will produce blurry images.
Scan at 600+ DPI, preferably 1200. You can save a lot of time by scanning multiple coins at the same time and then cropping them afterwards. I scan coins with this software. It was made to scan stamps but it was quite good at auto-cropping my coin scans, saving me a lot of time.